Bilateral testicular non-seminomatous germ cell tumor: case report
DOI:
https://doi.org/10.48193/embmbz04Keywords:
Orchiectomy, Chemotherapy, Nonseminomatous germ cell tumorAbstract
Clinical case description: a 32-year-old man with an increase in the volume of the left testicle and a decrease in the size of the right testicle, in addition to the presence of pain. A testicular ultrasound reported probable bilateral testicular neoplasia, while the contrast-enhanced tomography indicated a left testicular lesion suggestive of embryonal cell carcinoma. We performed a bilateral radical orchiectomy, and pathology reported a mixed germ cell tumor in both testicles. It was determined to be a non-seminomatous germ cell tumor stage IIIC, so the patient received chemotherapy, responding satisfactorily.
Clinical implications: the development of testicular germ cell tumors (TGCT) is generally associated with risk factors such as cryptorchidism and hypospadias. However, although our patient is in the age range related to the development of TGCT, he did not present these factors but did have an advanced clinical stage whose survival is lower in relation to earlier stages.
Relevance: the timely diagnosis and appropriate treatment of a non-seminomatous germ cell tumor stage IIIC enabled our patient to respond. Currently, he is monitoring.
Conclusions: survival in advanced clinical stage TGCT requires timely diagnosis and treatment, as well as follow-up, given the different complications that may arise.
References
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians. 2021;71(3): 209–249. https://doi.org/10.3322/caac.21660.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA: a cancer journal for clinicians. 2018;68(1): 7–30. https://doi.org/10.3322/caac.21442.
Oldenburg J, Berney DM, Bokemeyer C, Climent MA, Daugaard G, Gietema JA, et al. Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up. Annals of Oncology: Official Journal of the European Society for Medical Oncology. 2022;33(4): 362–375. https://doi.org/10.1016/j.annonc.2022.01.002.
Patrikidou A, Cazzaniga W, Berney D, Boormans J, de Angst I, Di Nardo D, et al. European Association of Urology Guidelines on Testicular Cancer: 2023 Update. European Urology. 2023;84(3): 289–301. https://doi.org/10.1016/j.eururo.2023.04.010.
Arranz Arija JA, Del Muro XG, Caro RL, Méndez-Vidal MJ, Pérez-Valderrama B, Aparicio J, et al. SEOM-GG clinical guidelines for the management of germ-cell testicular cancer (2023). Clinical & Translational Oncology: Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2024;26(11): 2783–2799. https://doi.org/10.1007/s12094-024-03532-2.
Gillessen S, Sauvé N, Collette L, Daugaard G, de Wit R, Albany C, et al. Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2021;39(14): 1563–1574. https://doi.org/10.1200/JCO.20.03296.
Tanuma K, Kawai K, Nitta S, Shiga M, Kawahara T, Negoro H, et al. Improved survival of poor-risk non-seminomatous germ cell tumor patients: real-world data from a single institute in Japan. Japanese Journal of Clinical Oncology. 2023;53(1): 74–79. https://doi.org/10.1093/jjco/hyac151.
Kirby M. Testicular cancer: low testosterone and the metabolic syndrome. Trends in Urology & Men’s Health. 2020;11(1): 12–17. https://doi.org/10.1002/tre.728.
Mulhall JP, Trost LW, Brannigan RE, Kurtz EG, Redmon JB, Chiles KA, et al. Evaluation and Management of Testosterone Deficiency: AUA Guideline. The Journal of Urology. 2018;200(2): 423–432. https://doi.org/10.1016/j.juro.2018.03.115.
Nicu AT, Medar C, Chifiriuc MC, Gradisteanu Pircalabioru G, Burlibasa L. Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care. Frontiers in Cell and Developmental Biology. 2022;10: 861995. https://doi.org/10.3389/fcell.2022.861995.
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